This is the first Calvin and Hobbes strip (1985) that appeared as the write up below the strip indicates. (Click on the pictures to see them bigger and the words will be more legible.)
This is the last strip published in a newspaper as a particular web site informs me and I have not been able to confirm it. But the last strip appeared sometime in 1995 when Watterson 'retired'.
The one below is one of my favorites.